Capto™ L is a bioprocessing chromatography resin for the capture of antibodies and antibody fragments. It combines a rigid, high-flow agarose matrix with the immunoglobulin-binding recombinant protein, L ligand, which has a strong affinity to the variable region of antibody kappa light chains. It is suitable for the capture of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs).
- High binding capacity, low ligand leakage, and selectivity for a broad range of antibody fragments reduces process time and amount of medium
- Enables a platform approach for purification of antibody fragments
- Increased productivity, process economy, and process design flexibility due to rigid matrix