The XMG1.2 antibody is specific for mouse Interferon-gamma (IFN-g), a 20 kDa type II cytokine known for its central roles in protection against bacterial or viral pathogens and for its anti-tumor properties. IFN-g is secreted by several types of immune cells, which allow the cytokine to modulate innate immunity, when secreted by NK and NKT cells, and to function in supporting adaptive immunity when secreted by Th1 and CD8+ T cells (CTLs).
The XMG1.2 antibody is suitable for detection of intracellular IFN-g protein by flow cytometry. Other formats can be used for quantitative analysis of the secreted protein by ELISA, when paired with an appropriated secondary antibody. This clone has been reported for neutralization of the functional activity of IFN-g in a variety of assays (use format suitable for functional assays).
Antigen: IFNG (interferon, gamma)
Conjugation: violetFluor® 450
Isotype: IgG1 Kappa