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Anti-APE1 Rabbit Polyclonal Antibody

Dodavatel: Thermo Scientific
In IHC applications, this antibody can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein. This antibody can be used on frozen sections, fixed-paraffin sections and cytospin preps. Suggested positive control: Hela whole cell extract, antigen standard for APEX1 (transient overexpression lysate). The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.

Type: Primary
Antigen: APE1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat, Rabbit, Primates, Human



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Rozměry protilátky Bal. VWR katalogové číslo Množství
100 µL 100 µl PIEAPA116500 Blocked
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Produktová specifikace

Symbol antigenu APE1
Název antigenu APE1
Reaktivita Rat, Mouse, Human, Primates, Rabbit
Spojení Unconjugated
Klonovalita Polyclonal
Druh protilátky Primary
Hostitel Rabbit
Isotyp IgG
Western Blot Yes
Imunochemie Yes
Imunoprecipitace Yes
Imunofluorescence Yes
ChIP Yes
Neutralizace Yes
Synonyma antigenu AP endonuclease class I, APE1, Apurinic Endonuclase Factor 1, Apurinic/apy, APEN, AP lyase, APEX nuclease, Apurinic/apyrimidinic (abasic) endonuclease
Gene ID 328, 79116, 11792
Koncentrace 0.5 mg/ml
Imunogen Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein
Čištění Antigen affinity chromatography
Forma Liquid
Skladovací pufr tris glycine, 0.15M NaCl, 0.05% sodium azide
Skladovací teplota -20° C, Avoid Freeze/Thaw Cycles
Transportní teplota Ice
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