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Anti-APE1 Rabbit Polyclonal Antibody

Dodavatel: Thermo Fisher Scientific
PIEAPA116500EA 0 CZK
PIEAPA116500
Anti-APE1 Rabbit Polyclonal Antibody
Protilátky
In IHC applications, this antibody can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein. This antibody can be used on frozen sections, fixed-paraffin sections and cytospin preps. Suggested positive control: Hela whole cell extract, antigen standard for APEX1 (transient overexpression lysate). The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.

Type: Primary
Antigen: APE1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat, Rabbit, Primates, Human
Objednat

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