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Anti-Carbonic Anhydrase IX Rabbit Polyclonal Antibody

Dodavatel: Thermo Scientific
Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma. Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Type: Primary
Antigen: Carbonic Anhydrase IX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Plant, Canine, Mouse, Rat




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100 µL 100 µl PIEAPA116592 Blocked
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Produktová specifikace

Symbol antigenu Carbonic Anhydrase IX
Název antigenu Carbonic Anhydrase 9
Reaktivita Human, Mouse, Plant, Rat, Dog
Spojení Unconjugated
Klonovalita Polyclonal
Druh protilátky Primary
Hostitel Rabbit
Isotyp IgG
Western blot Yes
ELISA Yes
Imunochemie Yes
Imunoprecipitace Yes
Imunofluorescence Yes
Posun gelu Yes
Průtoková cytometrie Yes
ChIP Yes
Synonyma antigenu CA9, P54 / 58N, CAIX, pMW1, Carbonic dehydratase, Renal cell carcinoma associated antigen G250, RCC associated protein G250, Membrane antigen MN
Gene ID 611933, 313495, 230099, 768
Koncentrace 1.0 mg/ml
Imunogen A synthetic peptide derived from a C-terminal sequence of the human CA IX.
Čištění Antigen affinity chromatography
Forma Liquid
Skladovací pufr PBS, 0.025% sodium azide
Skladovací teplota -20° C, Avoid Freeze/Thaw Cycles
Transportní teplota Ice
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