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Anti-Carbonic Anhydrase IX Rabbit Polyclonal Antibody

Dodavatel: Thermo Fisher Scientific
PIEAPA116592EA 0 CZK
PIEAPA116592
Anti-Carbonic Anhydrase IX Rabbit Polyclonal Antibody
Protilátky
Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma. Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Type: Primary
Antigen: Carbonic Anhydrase IX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Plant, Canine, Mouse, Rat
Objednat

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