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Anti-HMGB1 Rabbit Polyclonal Antibody

Dodavatel: Thermo Scientific
This antibody is expected to cross react with porcine, equine and rabbit samples based on 100% sequence homology. Suggested positive control: Hela whole cell extract, antigen standard for HMGB1 (transient overexpression lysate). HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. These proteins (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. They may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

Type: Primary
Antigen: HMGB1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Canine, Bovine, Human, Mouse, Rat, Ovine



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100 µL 100 µl PIEAPA116926 Blocked
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TECHNICKÉ ÚDAJE

Symbol antigenu HMGB1
Název antigenu High-mobility Group Box 1
Reaktivita Dog, Bovine, Rat, Human, Mouse, Ovine
Spojení Unconjugated
Klonovalita Polyclonal
Druh protilátky Primary
Hostitel Rabbit
Isotyp IgG
Western Blot Yes
Imunochemie Yes
Imunofluorescence Yes
Průtoková cytometrie Yes
Synonyma antigenu HMG3 antibody, High mobility group protein 1 antibody, High Mobility Group Box 1 antibody, High mobility group 1 antibody, Amphoterin antibody, Hmgb1
Gene ID 101112071, 25459, 3146, 282691, 403170, 15289
Koncentrace 1 mg/ml
Imunogen Synthetic peptide between to amino acids 100-200 of the human HMGB1 protein.
Čištění Antigen affinity chromatography
Forma Liquid
Skladovací pufr tris glycine, 0.02% sodium azide
Skladovací teplota 4° C, do not freeze
Transportní teplota Ice
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