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Anti-CD11b Rat Monoclonal Antibody (In Vivo Ready™) [clone: M1/70]

Dodavatel: Tonbo Biosciences
40-0112-U100EA 2890 CZK
40-0112-U100
Anti-CD11b Rat Monoclonal Antibody (In Vivo Ready™) [clone: M1/70]
Protilátky
The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165 to 170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

Type: Primary
Antigen: CD11b
Clonality: Monoclonal
Clone: M1/70
Conjugation: In Vivo Ready™
Epitope:
Host: Rat
Isotype: IgG2b, kappa
Reactivity: Human, Mouse, Chimpanzee, Baboon, Cynomolgus, Rhesus
Objednat

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