Hollow fibre filter modules are particularly useful in tangential flow filtration because processes can easily be scaled-up from small volume applications to full-scale production.
- Hollow fibre membranes are anisotropic in structure
- Filter housings are engineered to handle higher pressures and autoclaving
- Low protein binding increases the product yield of each processing run
- These filters have FLL/FLL connections and come in three effective lengths
Tangential flow filtration is used in both microfiltration and ultra-filtration applications. Ultra-filtration membranes have a high-density skin layer for less fouling and a fairly open outer support structure for increased filtration rates. Micro filtration membranes have a retention defining microporous outer skin and a more open inner layer for increased filtration with higher recoveries. Single-use eliminates the need for costly stainless-steel systems and increases manufacturing flexibility.
Mixed cellulose ester (ME) is a hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times and low protein binding for higher product yields. ME filter chemistry is also highly biocompatible making it useful for filtration applications with cells and cell and virus lysates.