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Anti-p53 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3036R-100EA 6910 CZK
BIOV3036R-100
Anti-p53 Rabbit Polyclonal Antibody
Protilátky
p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression throμgh the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min;p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml

Type: Primary
Antigen: p53
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Dog, Rabbit
Objednat

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