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Anti-Phospho-FoxO4/AFX Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3270-100EA 9170 CZK
BIOV3270-100
Anti-Phospho-FoxO4/AFX Rabbit Polyclonal Antibody
Protilátky
The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX, AND FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253.

Recommended Dilutions: Western Blot: 1-2 µg/ml

Type: Primary
Antigen: Phospho-FoxO4/AFX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
Objednat

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