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Anti-Cathepsin D Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3191R-100EA 7190 CZK
BIOV3191R-100
Anti-Cathepsin D Rabbit Polyclonal Antibody
Protilátky
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence sμggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml; in immunoprecipitation

Type: Primary
Antigen: Cathepsin D
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Objednat

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