The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB;MMP catalysis requires both calcium and zinc. MMP-13 (also designated collagenase-3) is produced by breast carcinomas and degrades collagen type I, II, III.
Recommended Dilutions: Western Blot: 0.5-4 µg/ml; immunoprecipitation and Immunohistochemistry: works with paraffin imbedded sections
Reactivity: Human, Mouse, Rat, Horse, Bovine