AMPK gamma-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK;AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Recommended Dilutions: ELISA: 0.25 µg/ml; Western Blot: 0.5-2.5 µg/ml; Immunohistochemistry: 2.5-5.0 µg/ml).
Antigen: AMPK beta
Reactivity: Human, Mouse