p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cell cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines, UV light and growth factors, etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.
Recommended Dilutions: Western Blot: 0.5-4 µg/ml; Immunoprecipitation: 10-20 µg/ml; and Immunohistochemistry: 10-20 µg/ml
Antigen: p38 MAP Kinase
Reactivity: Human, Mouse, Rat