The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK;AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart sμggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Recommended Dilutions: ELISA: 0.25 µg/ml; Western Blot: 2.5-5.0 µg/ml; Immunohistochemistry: 5-25 µg/ml).
Antigen: AMPK alpha 2
Reactivity: Human, Mouse