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Anti-PARP (Cleaved) Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3141-100EA 10290 CZK
BIOV3141-100
Anti-PARP (Cleaved) Rabbit Polyclonal Antibody
Protilátky
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavege occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa;It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml; Immunocytochemistry: 10-20 µg/ml

Type: Primary
Antigen: PARP (Cleaved)
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-terminal
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
Objednat

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