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Anti-Phospho-Stat3 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3474-100EA 9170 CZK
BIOV3474-100
Anti-Phospho-Stat3 Rabbit Polyclonal Antibody
Protilátky
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Recommended Dilutions: Western Blot: 1-4 µg/ml; Immunoprecipitation: 20 mg/ml; and Immunohistochemistry: 20 µg/ml

Type: Primary
Antigen: Phospho-Stat3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
Objednat

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