PTEN (phosphatase and tensin homologue deleted on chromosome ten) phosphatase is a tumor suppressor gene implicated in a wide variety of human cancers. PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K;PTEN is a major negative regulator of the PI3K/Akt signaling pathway.
Recommended Dilutions: Western Blot: 1-2 µg/ml; Immunoprecipitation: 10-20 µg/ml
Reactivity: Human, Mouse, Rat