UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin protein ligase. It may participate in methylation dependent transcriptional regulation. UHRF1 binds to inverted 5'CCAAT3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD (UHRF1) binding to unmodified H3R2.
Recommended Dilutions: Western Blot: 1:500-1:2000, IHC: 1:50-1:200, Immunofluorescence: 1:20-1:50, IP: 1:20-1:50, CHIP: 1:20-1:50