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Anti-TDG Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV6157-100EA 9450 CZK
BIOV6157-100
Anti-TDG Rabbit Polyclonal Antibody
Protilátky
In the DNA of higher eukaryotes, hydrolytic deamination of 5­methylcytosine to thymine leads to the formation of G/T mismatches. G/T mismatch specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon nitrogen bond between the sugar phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin­like proteins SUMO­1 and SUMO­2/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G/U substrate and the loss of G/T processing activity.

Recommended Dilutions: Western Blot: 1:500-1:1000.

Type: Primary
Antigen: TDG
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Objednat

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