Anti-GFRalpha-1 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV6201-100EA 7470 CZK
Anti-GFRalpha-1 Rabbit Polyclonal Antibody
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRα, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRα from human, rat, chicken and mouse have been cloned recently. GDNFRα was also termed Ret ligand 1 (RETL1) or TGF-β-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα-1 recently. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK;Thus, GDNF, GFRα and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml

Type: Primary
Antigen: GFRalpha-1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Více About VWR