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Anti-ACHE Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV6706-100EA 6910 CZK
BIOV6706-100
Anti-ACHE Rabbit Polyclonal Antibody
Protilátky
Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. It plays a role in neuronal apoptosis. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.

Recommended Dilutions: Western Blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:10-1:50, Immunofluorescence: 1:10-1:50.

Type: Primary
Antigen: ACHE
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human
Objednat

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