CCL2 is one of several cytokine genes clustered on the q-arm of chromosome 17. It is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Recommended Dilutions: Western Blot: ~1:1000, IHC: ~1:10–1:50, Immunofluorescence: ~1:10–1:50, FACS: ~1:10-1:50.