Anti-NGFR Mouse Monoclonal Antibody [clone: 8G3G10]

Dodavatel: BioVision
BIOV6789-100EA 6910 CZK
Anti-NGFR Mouse Monoclonal Antibody [clone: 8G3G10]
NGFR, a 75 kd glycoprotein (also known as P-75NTR), is the first of neurotrophin receptors to be isolated and is a member of the tumor necrosis factor (TNF) receptor family. It is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, and neurotized nevi (type C melanocytes;NGFR has been shown to be a reliable marker for desmoplastic and neurotropic melanoma by several groups. It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature nonneural cells such as perivascular cells, follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells and myoepithelial cells. Studies in prostate and urothelial cancer suggest that NGFR may act as a tumour suppressor, negatively regulating cell growth and proliferation. Anti-NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts and thus aides in the diagnosis of malignancy in the breast.

Recommended Dilutions: Western Blot: 1:500-1:2000, IHC: 1:50-1:100, Immunofluorescence: 1:100.

Type: Primary
Antigen: NGFR
Clonality: Monoclonal
Clone: 8G3G10
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human.

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