Anti-DRAM Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV5075-100EA 9170 CZK
Anti-DRAM Rabbit Polyclonal Antibody
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been sμggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and sμggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Recommended Dilutions: Western Blot: 0.5-2 ?g/ml, Immunohistochemistry: 2.5 ?g/ml, ELISA

Type: Primary
Antigen: DRAM
Clonality: Polyclonal
Conjugation: Unconjugated
Epitope: N-terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat

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