Anti-SHANK3 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV5317-100EA 10570 CZK
Anti-SHANK3 Rabbit Polyclonal Antibody
SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.

Recommended Dilutions: Western Blot: 1 ?g/ml, IHC: 2.5 ?g/ml, ELISA

Type: Primary
Antigen: SHANK3
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse

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