Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family throμgh their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.
Recommended Dilutions: Western Blot: 0.5-4 µg/ml
Reactivity: Human, Mouse, Rat