Tisk…

Anti-Caspase-12 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3282-100EA 7900 CZK
BIOV3282-100
Anti-Caspase-12 Rabbit Polyclonal Antibody
Protilátky
Three distinct signaling pathways lead to programmed cell death (apoptosis;The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and β-amyloid precursor protein (APP;Caspase-12 mediates cytotoxicity induced by amyloid-β. Caspase-12 is ubiquitously expressed in mouse tissues.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml

Type: Primary
Antigen: Caspase-12
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat
Objednat

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Více About VWR