Tisk…

Anti-NFkB p50 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3354R-100EA 6910 CZK
BIOV3354R-100
Anti-NFkB p50 Rabbit Polyclonal Antibody
Protilátky
Nuclear factor kappa B (NFkB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA;Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50 has an isoform called p49/p52, and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines (IL-1 & TNF, etc.), and viral infection, IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml

Type: Primary
Antigen: NFkB p50
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Objednat

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Více About VWR