Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drμg abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999;TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004;The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002;Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
Recommended Dilutions: Western Blot: 1:1000; Iimmunofluorescence: 1:1000; Immunohistochemistry: 1:1000
Antigen: Phospho (Ser19) Tyrosine Hydroxylase
Reactivity: Mammals, Rat