Anti-PARP Mouse Monoclonal Antibody [clone: 839120]

Dodavatel: BioVision
BIOV6659-100EA 9170 CZK
Anti-PARP Mouse Monoclonal Antibody [clone: 839120]
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa;PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Recommended Dilutions: Western Blot: 1 µg/ml, IHC: 8-25 µg/ml.

Type: Primary
Antigen: PARP
Clonality: Monoclonal
Clone: 839120
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human

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