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Anti-IRS-1 Rabbit Polyclonal Antibody

Dodavatel: BioVision
BIOV3424-100EA 6910 CZK
BIOV3424-100
Anti-IRS-1 Rabbit Polyclonal Antibody
Protilátky
IRS-1 (Insulin receptor substrate-1) is phosphorylated in response to stimulation of cells by insulin. Upon ligand-induced phosphorylation, IRS-1 immediately associates with a series of SH2 domain-containing signaling intermediates such as PI3-kinase, GRB2, Syp and Nck. The level of diversity in structure and function of the SH2-containing proteins which binds activated IRS-1 is important for responsiveness to insulin. IRS phosphorylation elicits the growth and metablic effects of insulin growth factors and insulin by allowing glucose uptake, glycogen synthesis and mitogenic activity. IRS-1 migrates between 170 and 185 kDa and is expressed in most cell types.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml

Type: Primary
Antigen: IRS-1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Objednat

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