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Anti-S100A1 Mouse Monoclonal Antibody (CF488A) [clone: S100A1/1012]

Dodavatel: Biotium

BNC881012-100EA 5470 CZK
BNC881012-100 BNC881012-500
Anti-S100A1 Mouse Monoclonal Antibody (CF488A) [clone: S100A1/1012]
Protilátky
The family of EF-hand type Ca2 -binding proteins includes calbindin, S-100 alpha and beta, calgranulins, B and C, and the parvalbumin family members, including parvalbumin alpha and parvalbumin beta. The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. S-100 protein may function in the activation of Ca2 induced Ca2 release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain and S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of two alpha chains, two beta chains or one alpha and one beta chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann s cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha and beta are present in a variety of other tissues and calbindin is present in intestine and kidney.

Type: Primary
Antigen: S100A1
Clonality: Monoclonal
Clone: S100A1/1012
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Cow, Human, Mouse, Rat
Objednat

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