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Anti-CD4 Rat Monoclonal Antibody (APC-Cyanine7) [clone: GK1.5]

Dodavatel: Tonbo Biosciences
25-0041-U025EA 2040 CZK
25-0041-U025 25-0041-U100
Anti-CD4 Rat Monoclonal Antibody (APC-Cyanine7) [clone: GK1.5]
Protilátky
The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will "compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

Type: Primary
Antigen: CD4
Clonality: Monoclonal
Clone: GK1.5
Conjugation: APC-Cyanine7
Epitope:
Host: Rat
Isotype: Rat IgG2b, kappa
Reactivity: Mouse, Syrian Hamster
Objednat

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