Anti-COMMD10 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Dodavatel: Bioss
BOSSBS-8181R-A350EA 24190 CZK
Anti-COMMD10 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
COMMD or COMM is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms and define a novel family of structural and functional homologs of MURR1. The prototype of this family, MURR1/COMMD1, suppresses NFkB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs; rather, it functions in the nucleus by affecting the association of NF-kappaB with chromatin.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: COMMD10
Clonality: Polyclonal
Conjugation: Alexa Fluor® 350
Host: Rabbit

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