Anti-DEPTOR Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Dodavatel: Bioss
BOSSBS-8255R-A647EA 24780 CZK
Anti-DEPTOR Rabbit Polyclonal Antibody (Alexa Fluor® 647)
DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: DEPTOR
Clonality: Polyclonal
Conjugation: Alexa Fluor® 647
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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