Anti-FBXW8 Rabbit Polyclonal Antibody (Cy5®)

Dodavatel: Bioss
BOSSBS-8395R-CY5EA 24190 CZK
Anti-FBXW8 Rabbit Polyclonal Antibody (Cy5®)
FBXO29, also designated F-box/WD repeat-containing protein 8 (FBXW8), is a 598 amino acid protein that contains one 40 amino acid F-box region, making it a member of the F-box family. FBXO29 also contains five WD repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO29 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. FBXO29 exists as two isoforms as a result of alternative splicing events.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: FBXW8
Clonality: Polyclonal
Conjugation: Cy5®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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