Anti-FNDC3B Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Dodavatel: Bioss
BOSSBS-8487R-A555EA 24190 CZK
Anti-FNDC3B Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: FNDC3B
Clonality: Polyclonal
Conjugation: Alexa Fluor® 555
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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