Tisk…

Ivacaftor

Dodavatel: BioVision
BIOV9582-25EA 17000 CZK
BIOV9582-25 BIOV9582-5
Ivacaftor
Ivacaftor (VX-770) is a potent, cell-permeable small molecule potentiator of cystic fibrosis transmembrane conductance regulator (CFTR).

  • Increases the forskolin-induced CFTR-mediated epithelial current in cells
  • Has no effect on current in the absence of forskolin
  • Increases chloride secretion in cultured human CF bronchial epithelial cells

It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D mutation by ~4-fold (EC₅₀ = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human CF bronchial epithelial cells carrying the G551D mutation on one allele and the common F508del processing mutation on the other allele. It binds CFTR directly and causes CFTR channel opening by an ATP-independent mechanism. It effectively improves sweat chloride in vivo while improving lung function when at least one G551D CFTR mutation is present.

Appearance: Off-white solid
CAS number: 873054-44-5
Molecular Formula: C₂₄H₂₈N₂O₃
Molecular Weight: 392,49
Purity: ≥98% by HPLC
Solubility: DMSO (>50 mg/ml)
MDL number: MFCD17171361
Handling: Protect from air and light
Storage conditions: –20 °C
Alternate Name: N-​[2,​4-​bis(1,​1-​dimethylethyl)​-​5-​hydroxyphenyl]​-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxamide; Cystic Fibrosis Transmembrane Conductance Regulator Potentiator; VX770; Kalydeco
Objednat

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Více About VWR