Benzo[a]pyren ≥96% (by HPLC), Sigma-Aldrich®Dodavatel: Merck
M-Clarity™ quality level = MQ200
Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer.
Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.
MW: 252,32 g/mol
Bod varu: 495 °C (1013 hPa)
Bod tání: 176…178 °C
Hustota: 1,351 g/cm³ (20 °C)
CAS číslo: 50-32-8
Merck Index: 12,01134